Rebound excitation triggered by synaptic inhibition in 2 cerebellar nuclear neurons is suppressed by selective T - 3 type calcium channel block 4 5 6
نویسندگان
چکیده
Rebecca Boehme, Victor N. Uebele, John J. Renger 4 and Christine Pedroarena 7 1,2 8 9 Department of Cognitive Neurology, Hertie Institute for Clinical Brain Research, 10 Systems Neurophysiology Group, Werner Reichardt Centre for Integrative Neuroscience, Graduate 11 School for Neural and Behavioral Sciences, University of Tübingen, Otfried MüllerStr 27, 72076 Tübingen, 12 Germany. 13 Merck Research Labs, 770 Sumneytown Pike , West Point, PA 19486, US 14 15
منابع مشابه
Rebound excitation triggered by synaptic inhibition in cerebellar nuclear neurons is suppressed by selective T-type calcium channel block.
Following hyperpolarizing inputs, many neurons respond with an increase in firing rate, a phenomenon known as rebound excitation. Rebound excitation has been proposed as a mechanism to encode and process inhibitory signals and transfer them to target structures. Activation of low-voltage-activated T-type calcium channels and the ensuing low-threshold calcium spikes is one of the mechanisms prop...
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Neurons in the cerebellar nuclei fire at accelerated rates for prolonged periods after trains of synaptic inhibition that interrupt spontaneous firing. Both in vitro and in vivo, however, this prolonged rebound firing is favored by strong stimulation of afferents, suggesting that neurotransmitters other than GABA may contribute to the increased firing rates. Here, we tested whether metabotropic...
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T-type calcium channels are thought to transform neuronal output to a burst mode by generating low voltage-activated (LVA) calcium currents and rebound burst discharge. In this study we assess the expression pattern of the three different T-type channel isoforms (Ca(v)3.1, Ca(v)3.2, and Ca(v)3.3) in cerebellar neurons and focus on their potential role in generating LVA spikes and rebound discha...
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In this study, involvement ofvoltage-dependent calcium channels in LTP of responses of rat visual cortex slices was analyzed. Field potentials including EPSP1 and EPSP2 from layers II/III were recorded through stimulation of layer IV. Whereas nifedipine, a L-type calcium channel blocker (L-VDCC), did not considerably affect the LTP of responses, but Ni2+, a relatively selective blocker of T-typ...
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